ABSTRACT
Background: Liver transplantation often necessitates the use of immunosuppressive drugs to prevent rejection. However, the impact of these drugs on the immune system, particularly on natural killer (NK) cells, remains a subject of investigation.
Aim: This study aimed to investigate the influence of immunosuppressive drugs on NK cells during therapeutic drug exposure in liver transplantation.
Methods: A prospective study was conducted from November 2022 and November 2023, involving 90 patients undergoing liver transplantation. Peripheral blood samples were collected at regular intervals post-transplantation to assess NK cell populations using flow cytometry. Immunosuppressive drug levels were monitored concurrently.
Results: Our results revealed significant alterations in NK cell populations following exposure to immunosuppressive drugs. Specifically, a decrease in the absolute count and functional activity of NK cells was observed with increasing concentrations of immunosuppressants.
Conclusion: Immunomodulatory effects of immunosuppressive drugs on NK cells were evident in liver transplant recipients. Understanding these dynamics is crucial for optimizing immunosuppressive regimens and minimizing the risk of complications post-transplantation.
Keywords: Liver transplantation, Immunosuppressive drugs, Natural killer cells, Therapeutic drug exposure, Flow cytometry.