Volume 13 Issue 10
In-depth clinical and translational assessment of the role of stem cell therapy in orthopedic regeneration: Critical insights into cartilage and bone repair through modern regenerative approaches
¹Dr. Mohammed Akhtar Khan, ²Dr. Aurangzaib Hamid, ³Dr. Nadia Salam, ⁴Dr. Fatima Murtaza, ⁵Dr. Zain Ul Abideen, ⁶Dr. Huma Zahid
¹Consultant Surgeon / Head of the Department of Orthopedics, NSHS SZABIST
²Medical Officer, NSHS SZABIST
³Hospital Avicenna Medical and Dental College
⁴Consultant Oncologist, Shaukat Khanum Memorial Cancer Hospital, Lahore
⁵Assistant Professor, Bolan Medical College, Quetta
⁶Associate Professor, Punjab Medical College, Faisalabad
ABSTRACT:
Background: Clinicians face major challenges when treating orthopedic injuries that affect cartilage and bone because natural healing capacity is poor. The insufficient capabilities of traditional treatments lead doctors to investigate stem cell therapy to repair the body. The ability of stem cells to multiply makes them an emerging promising option for orthopedic tissue regeneration.
Aim: The research evaluated stem cell therapy for orthopedic healing especially in cartilage and bone repair functions.
Methods: A comprehensive observational research took place at Ayub Medical Hospital, Abbottabad from February 2024 until January 2025. One hundred patients received stem cell-based therapy because they had cartilage or bone defects. Standard assessment tools along with imaging tests evaluated clinical and functional status together with radiological changes of patients before treatment and after treatment completion. Healthcare providers tracked patient outcomes of pain relief and enhanced mobility as well as better tissue formation.
Results: Clinical data confirmed that stem cell therapy successfully healed both cartilage and bone tissues in most investigated patients. Twelve patients up to 65 years old received stem cell treatments after a surgical procedure to study cartilage-bone healing. X-ray images revealed tissue regeneration in 76% of cases and 81% of patients reported lower joint pain and better knee movement. All tested age groups tolerated the treatment without major adverse reactions during the investigation period. The methodology included histological assessments which proved that the patients developed new hyaline-like cartilage and bone tissues.
Conclusion: Orthopedic patients showed positive results from stem cell therapy which established itself as a both safe and effective method to regenerate cartilage and bone tissues. The regenerative potential of structural and functional recovery attributes stem cell therapy to become a transformative method for orthopedic regenerative medicine. Additional lengthy research involving randomized controlled trials should validate current results and develop standardized procedures.
Keywords: Stem cell therapy, orthopedic regeneration, cartilage repair, bone healing, regenerative medicine, tissue engineering
