Abstract
Objectives:
To determine the correlation of HbA1c with mean serum lipid profile parameters.
To compare mean lipid profile among type 2 diabetics with ≤7 and >7 HbA1c.
Materials and Methods:  The present Cross Sectional study was approved by the REU of CPSP and conducted at Holy Family Hospital, Rawalpindi, involving both inpatients and diabetic clinic attendees who met the criteria. After obtaining written consent, demographic and clinical data were recorded, including diabetes duration and comorbidities. Fasting lipid profile and HbA1c were measured using the AU680 machine. Data were grouped by HbA1c levels (≤7% and >7%) and analyzed using SPSS Version 25.
Results: The mean age was 58.15±11.88 years, with diabetes duration averaging 6.47±1.85 years. Most patients were male (58%), urban (56.5%), and literate (70%). HbA1c was ≤7% in 41.5% and >7% in 58.5%. Lipid levels showed no significant differences between HbA1c groups, except for HDL, which was significantly higher in the ≤7% group (p=0.006). Pearson correlation showed a negative link only between HbA1c and HDL (r=–0.191, p=0.006). Post-stratification revealed significantly higher HDL in males, those aged 40–50, and urban residents with HbA1c ≤7%, while other lipid values showed no significant variation.
Conclusion: It was concluded that HDL cholesterol exhibited a significant inverse association with HbA1c in patients with T2DM, whereas other lipid parameters showed no notable variation with glycemic control. These findings highlight the importance of monitoring and managing HDL cholesterol as part of diabetes care to help reduce cardiovascular risk..
Key words:  HbA1c, lipid profile, type 2 diabetes.