Submission 16 July 2025
Acceptance 20 Aug 2025
Publication 20 October 2025
Volume 13 Issue 10
EFFICACY OF ORAL OFLOXACIN VERSUS CEFOTAXIME IN UNCOMPLICATED SPONTANEOUS BACTERIAL PERITONITIS IN CIRRHOTIC PATIENTS
1Dr. Arifa Sattar, 2Dr. Prof Hakim Ali Abro, 3Dr. Suhana, 4Dr. Sultan Ahmed Chandio, 5Dr. Kamlesh Kumar Ahuja, 6Dr. Afsheen Memon, 7Dr. Javeria Tunio, 8Dr. Komal, 9Dr. Maryam, 10Dr. Nausheen Ali
1Chandka Medical College Hospital SMBBMU Larkana, Postgraduate Trainee Resident FCPS 2 (Internal Medicine), MBBS, FCPS 1
2Chandka Medical College Hospital SMBBMU Larkana Professor of Medicine, MBBS, MCPS, FCPS, FPSIM, FRCP (GLASG)
3Khairpur Medical College, 3rd Year Medical Student, MBBS (Pursuing)
4Chandka Medical College Hospital SMBBMU Larkana, Associate Professor of Medicine, MBBS, FCPS, FRCP (GLASG), FACP
5Chandka Medical College Hospital SMBBMU Larkana, Assistant Professor, MBBS, MCPS, FCPS, FRCP (GLASG), PSIM, CHPE
6Chandka Medical College Hospital (SMBBMU) Larkana, Consultant Physician, MBBS, FCPS
7Chandka Medical College Hospital (SMBBMU) Larkana Medical Officer, MBBS
8Chandka Medical College Hospital (SMBBMU) Larkana, Postgraduate Resident Trainee FCPS 2 (Internal Medicine), MBBS, FCPS
9Khairpur Medical College, 3rd year Medical Student MBBS (Pursuing)
10Chandka Medical College Hospital SMBBMU Larkana, Postgraduate Resident FCPS-2 Trainee (Internal Medicine), MBBS, FCPS 1
ABSTRACT
OBJECTIVE
To compare the efficacy of Ofloxacin versus Cefotaxime in the treatment of uncomplicated spontaneous bacterial peritonitis among liver cirrhotic patients.
METHODOLOGY
This study was a randomized controlled trial performed at the Medical Unit 1 of the Chandka Medical College Hospital Larkana where 288 patients (144 patients in each group) aged between 18 and 60 years with uncomplicated SBP associated with liver cirrhosis were included. A patient in group A (Ofloxacin) was treated with oral Ofloxacin 400 mg per day, a patient in group B (Cefotaxime) was administered with Cefotaxime 2 g intravenously three times a day; the two therapeutic regimens were observed and compared. The statistical analysis was carried out using SPSS version 26 and the p-value of 0.05 was considered as the cut off value for the level of significance.
RESULTS
A total of 288 cirrhotic patients with uncomplicated spontaneous bacterial peritonitis (SBP) were included. The mean age of patients in the Ofloxacin group was 42.30 ± 12.10 years, while in the Cefotaxime group it was 39.52 ± 12.35 years. A higher proportion of females was observed in both groups, with 52.1% in the Ofloxacin group and 59.7% in the Cefotaxime group. Ofloxacin was effective in 80.6% of patients, compared to 79.2% in the Cefotaxime group this difference was not statistically significant (p = 0.769). These findings suggest that oral Ofloxacin is not inferior to Cefotaxime in the treatment of uncomplicated spontaneous bacterial peritonitis.
CONCLUSION
Ofloxacin and Cefotaxime demonstrated comparable efficacy in the treatment of uncomplicated spontaneous bacterial peritonitis among cirrhotic patients. Oral Ofloxacin is not inferior to Cefotaxime and represents a practical alternative, particularly in settings where oral therapy is preferred or more feasible.
KEYWORDS
Anti-bacterial agents, Bacterial infections, Cefotaxime, Cirrhosis, Ofloxacin, Spontaneous bacterial peritonitis
