Volume 13 Issue 10
Submission 15 July 2025
Acceptance 21 Aug 2025
Publication 9 October 2025
Comprehensive Advances in Valvular Heart Disease: Current Treatment Alternatives and New Therapeutic Paradigms
1Isma Abbass, 2Dr Muhammad Zubair Faiz, 3Danish Marwat, 4Tahmoor Ghori, 5Haroon Raja, 6Asad Jahangir
1UHS, Lahore
2Rawalpindi Institute of Cardiology, Rawalpindi
3Sir Gangaram Hospital, Lahore
4Service Hospital, Lahore
5PIMS, Islamabad
6Mayo Hospital, Lahore
Abstract
Background: Valvular heart disease (VHD) is a wide range of structural and functional Valvular cardiac abnormalities leading to severe cardiovascular morbidity and mortality worldwide.
Objective: The paper summarizes current treatment techniques, i.e., medical, surgical, and trans catheter therapy, highlighting new trends, clinical results, and evolving paradigms of care.
Methods: A 2015-2025 narrative study of peer-studyed literature, clinical trials, and guideline recommendations was performed in PubMed, Scopus, and Google Scholar.
Results: Advances in surgical technology, such as minimally invasive and robotic surgery, have enhanced long-term outcomes. Trans catheter interventions, such as TAVR (Trans catheter Aortic Valve Replacement) and TEER (Trans catheter Edge-to-Edge Repair), have made the treatment of inoperable and high-risk patients possible.
Conclusion: The current treatment for VHD is moving toward individualized, minimally invasive, and image-guided therapy. The best outcome depends on early diagnosis, multidisciplinary assessment, and individualized therapeutic intervention selection.
Keywords: Valvular heart disease, aortic stenosis, mitral regurgitation, valve replacement, TAVR, TEER, surgical valve repair, minimally invasive cardiac surgery